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Acetic acid

Acetic acid, also known as ethanoic acid, is an organic chemical compound with the formula CH3COOH best recognized for giving vinegar its sour taste and pungent smell. Pure, water-free acetic acid (glacial acetic acid) is a colorless liquid that attracts water from the environment (hygroscopy), and freezes below 16.7°C (62°F) to a colourless crystalline solid. Acetic acid is corrosive, and its vapour causes irritation to the eyes, a dry and burning nose, sore throat and congestion to the lungs, however, it is considered a weak acid due to its limited ability to dissociate in aqueous solutions.[clarify]

Acetic acid
Acetic acid Acetic acid
General
Systematic name Acetic acid
Ethanoic acid
Other names Methanecarboxylic acid
Acetyl hydroxide (AcOH)
Hydrogen acetate (HAc)
Molecular formula CH3COOH
SMILES CC(=O)O
Molar mass 60.05 g/mol
Appearance Colourless liquid
or crystals
CAS number [64-19-7]
Properties
Density and phase 1.049 g cm−3, liquid
1.266 g cm−3, solid
Solubility in water Fully miscible
In ethanol, acetone
In toluene, hexane
In carbon disulfide
Fully miscible
Fully miscible
Practically insoluble
Melting point 16.5 °C (289.6 ± 0.5 K) (61.6 °F)[1]
Boiling point 118.1 °C (391.2 ± 0.6 K) (244.5 °F)[1]
Acidity (pKa) 4.76 at 25°C
Viscosity 1.22 mPa·s at 25°C
Dipole moment 1.74 D (gas)
Hazards
MSDS External MSDS
EU classification Corrosive (C)
NFPA 704
2
2
0
 
Flash point 43°C
R-phrases R10, R35
S-phrases (S1/2), S23, S26, S45
U.S. Permissible
exposure limit (PEL)
10 ppm
Supplementary data page
Structure
& properties
n, εr, etc.
Thermodynamic
data
Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
Related compounds
Related carboxylic
acids
Formic acid
Propionic acid
Butyric acid
Related compounds Acetamide
Ethyl acetate
Acetyl chloride
Acetic anhydride
Acetonitrile
Acetaldehyde
Ethanol
thioacetic acid
Except where noted otherwise, data are given for
materials in their standard state (at 25°C, 100 kPa)
Infobox disclaimer and references

 

Acetic acid is one of the simplest carboxylic acids (the second-simplest, next to formic acid). It is an important chemical reagent and industrial chemical that is used in the production of polyethylene terephthalate mainly used in soft drink bottles; cellulose acetate, mainly for photographic film; and polyvinyl acetate for wood glue, as well as many synthetic fibres and fabrics. In households diluted acetic acid is often used in descaling agents. In the food industry acetic acid is used under the food additive code E260 as an acidity regulator.

The global demand of acetic acid is around 6.5 million tonnes per year (Mt/a), of which approximately 1.5 Mt/a is met by recycling; the remainder is manufactured from petrochemical feedstocks or from biological sources.

Nomenclature

The trivial name acetic acid is the most commonly used and officially preferred name by the IUPAC. This name derives from acetum, the Latin word for vinegar. The synonym ethanoic acid is a systematic name that is sometimes used in introductions to chemical nomenclature.

Glacial acetic acid is a trivial name for water-free acetic acid. Similar to the German name Eisessig (literally, ice-vinegar), the name comes from the ice-like crystals that form slightly below room temperature at 16.7°C (about 62°F).

The most common and official abbreviation for acetic acid is AcOH or HOAc where Ac stands for the acetyl group CH3−C(=O)−;. In the context of acid-base reactions the abbreviation HAc is often used where Ac instead stands for the acetate anion (CH3COO), although this use is regarded by many as misleading. In either case, the Ac is not to be confused with the abbreviation for the chemical element actinium.

Acetic acid has the empirical formula CH2O and the molecular formula C2H4O2. The latter is often written as CH3-COOH, CH3COOH, or CH3CO2H to better reflect its structure. The ion resulting from loss of H+ from acetic acid is the acetate anion. The name acetate can also refer to a salt containing this anion, or an ester of acetic acid.

Chemical properties

Acidity

The hydrogen (H) atom in the carboxyl group (−COOH) in carboxylic acids such as acetic acid can be given off as an H+ ion (proton), giving them their acidic character. Acetic acid is a weak, effectively monoprotic acid in aqueous solution, with a pKa value of 4.8. Its conjugate base is acetate (CH3COO). A 1.0 M solution (about the concentration of domestic vinegar) has a pH of 2.4, indicating that merely 0.4% of the acetic acid molecules are dissociated.

Deprotonation equilibrium of acetic acid in water

Cyclic dimer

Cyclic dimer of acetic acid; dashed lines represent hydrogen bonds.
Cyclic dimer of acetic acid; dashed lines represent hydrogen bonds.

The crystal structure of acetic acid[5] shows that the molecules pair up into dimers connected by hydrogen bonds. The dimers can also be detected in the vapour at 120 °C. They also occur in the liquid phase in dilute solutions in non-hydrogen-bonding solvents, and to some extent in pure acetic acid,[6] but are disrupted by hydrogen-bonding solvents. The dissociation enthalpy of the dimer is estimated at 65.0–66.0 kJ/mol, and the dissociation entropy at 154–157 J mol–1 K–1.[7] This dimerisation behaviour is shared by other lower carboxylic acids.

Solvent

Liquid acetic acid is a hydrophilic (polar) protic solvent, similar to ethanol and water. With a moderate dielectric constant of 6.2, it can dissolve not only polar compounds such as inorganic salts and sugars, but also non-polar compounds such as oils and elements such as sulfur and iodine. It readily mixes with many other polar and non-polar solvents such as water, chloroform, and hexane. This dissolving property and miscibility of acetic acid makes it a widely used industrial chemical.

Chemical reactions

Acetic acid is corrosive to many metals including iron, magnesium, and zinc, forming hydrogen gas and metal salts called acetates. Aluminium, when exposed to oxygen, forms a thin layer of aluminium oxide on its surface which is relatively resistant, so that aluminium tanks can be used to transport acetic acid. Metal acetates can also be prepared from acetic acid and an appropriate base, as in the popular "baking soda + vinegar" reaction. With the notable exception of chromium(II) acetate, almost all acetates are soluble in water.

Mg(s) + 2 CH3COOH(aq) → (CH3COO)2Mg(aq) + H2(g)
NaHCO3(s) + CH3COOH(aq) → CH3COONa(aq) + CO2(g) + H2O(l)

Acetic acid undergoes the typical chemical reactions of a carboxylic acid, such producing ethanoic acid when reacting with alkalis, producing a metal ethanoate when reacted with a metal, and producing a metal ethanoate, water and carbon dioxide when reacting with carbonates and hydrogencarbonates. Most notable of all its reactions is the formation of ethanol by reduction, and formation of derivatives such as acetyl chloride via nucleophilic acyl substitution. Other substitution derivatives include acetic anhydride; this anhydride is produced by loss of water from two molecules of acetic acid. Esters of acetic acid can likewise be formed via Fischer esterification, and amides can also be formed. When heated above 440 °C, acetic acid decomposes to produce carbon dioxide and methane, or to produce ketene and water.

Detection

Acetic acid can be detected by its characteristic smell. A colour reaction for salts of acetic acid is iron(III) chloride solution, which results in a deeply red colour that disappears after acidification. Acetates when heated with arsenic trioxide form cacodyl oxide, which can be detected by its malodorous vapours.

Biochemistry

The acetyl group, derived from acetic acid, is fundamental to the biochemistry of virtually all forms of life. When bound to coenzyme A it is central to the metabolism of carbohydrates and fats. However, the concentration of free acetic acid in cells is kept at a low level to avoid disrupting the control of the pH of the cell contents. Unlike some longer-chain carboxylic acids (the fatty acids), acetic acid does not occur in natural triglycerides. However, the artificial triglyceride triacetin (glycerin triacetate) is a common food additive, and is found in cosmetics and topical medicines.

Acetic acid is produced and excreted by certain bacteria, notably the Acetobacter genus and Clostridium acetobutylicum. These bacteria are found universally in foodstuffs, water, and soil, and acetic acid is produced naturally as fruits and some other foods spoil. Acetic acid is also a component of the vaginal lubrication of humans and other primates, where it appears to serve as a mild antibacterial agent.[8]

Production

Purification and concentration plant for acetic acid in 1884
Purification and concentration plant for acetic acid in 1884

Acetic acid is produced both synthetically and by bacterial fermentation. Today, the biological route accounts for only about 10% of world production, but it remains important for vinegar production, as many of the world food purity laws stipulate that vinegar used in foods must be of biological origin. About 75% of acetic acid made for use in the chemical industry is made by methanol carbonylation, explained below. Alternative methods account for the rest.[9]

Total worldwide production of virgin acetic acid is estimated at 5 Mt/a (million tonnes per year), approximately half of which is produced in the United States. European production stands at approximately 1 Mt/a and is declining, and 0.7 Mt/a is produced in Japan. Another 1.5 Mt are recycled each year, bringing the total world market to 6.5 Mt/a.[10][11] The two biggest producers of virgin acetic acid are Celanese and BP Chemicals. Other major producers include Millennium Chemicals, Sterling Chemicals, Samsung, Eastman, and Svensk Etanolkemi.

Methanol carbonylation

Most virgin acetic acid is produced by methanol carbonylation. In this process, methanol and carbon monoxide react to produce acetic acid according to the chemical equation:

CH3OH + CO → CH3COOH

The process involves iodomethane as an intermediate, and occurs in three steps. A catalyst, usually a metal complex, is needed for the carbonylation (step 2).

(1) CH3OH + HI CH3I + H2O
(2) CH3I + CO → CH3COI
(3) CH3COI + H2O → CH3COOH + HI

By altering the process conditions, acetic anhydride may also be produced on the same plant. Because both methanol and carbon monoxide are commodity raw materials, methanol carbonylation long appeared to be an attractive method for acetic acid production. Henry Drefyus at British Celanese developed a methanol carbonylation pilot plant as early as 1925.[12] However, a lack of practical materials that could contain the corrosive reaction mixture at the high pressures needed (200 atm or more) discouraged commercialisation of these routes for some time. The first commercial methanol carbonylation process, which used a cobalt catalyst, was developed by German chemical company BASF in 1963. In 1968, a rhodium-based catalyst (cis���[Rh(CO)2I2]) was discovered that could operate efficiently at lower pressure with almost no by-products. The first plant using this catalyst was built by US chemical company Monsanto in 1970, and rhodium-catalysed methanol carbonylation became the dominant method of acetic acid production (see Monsanto process). In the late 1990s, the chemicals company BP Chemicals commercialised the Cativa catalyst ([Ir(CO)2I2]), which is promoted by ruthenium. This iridium-catalysed process is greener and more efficient[13] and has largely supplanted the Monsanto process, often in the same production plants.

Acetaldehyde oxidation

Prior to the commercialisation of the Monsanto process, most acetic acid was produced by oxidation of acetaldehyde. This remains the second most important manufacturing method, although it is uncompetitive with methanol carbonylation. The acetaldehyde may be produced via oxidation of butane or light naphtha, or by hydration of ethylene.

When butane or light naphtha is heated with air in the presence of various metal ions, including those of manganese, cobalt and chromium; peroxides form and then decompose to produce acetic acid according to the chemical equation

2 C4H10 + 5 O2 → 4 CH3COOH + 2 H2O

Typically, the reaction is run at a combination of temperature and pressure designed to be as hot as possible while still keeping the butane a liquid. Typical reaction conditions are 150 °C and 55 atm. Several side products may also form, including butanone, ethyl acetate, formic acid, and propionic acid. These side products are also commercially valuable, and the reaction conditions may be altered to produce more of them if this is economically useful. However, the separation of acetic acid from these by-products adds to the cost of the process.

Under similar conditions and using similar catalysts as are used for butane oxidation, acetaldehyde can be oxidised by the oxygen in air to produce acetic acid

2 CH3CHO + O2 → 2 CH3COOH

Using modern catalysts, this reaction can have an acetic acid yield greater than 95%. The major side products are ethyl acetate, formic acid, and formaldehyde, all of which have lower boiling points than acetic acid and are readily separated by distillation.

Ethylene oxidation

Fermentation

Oxidative fermentation

For most of human history, acetic acid, in the form of vinegar, has been made by bacteria of the genus Acetobacter. Given sufficient oxygen, these bacteria can produce vinegar from a variety of alcoholic foodstuffs. Commonly used feeds include apple cider, wine, and fermented grain, malt, rice, or potato mashes. The overall chemical reaction facilitated by these bacteria is:

C2H5OH + O2 → CH3COOH + H2O

A dilute alcohol solution inoculated with Acetobacter and kept in a warm, airy place will become vinegar over the course of a few months. Industrial vinegar-making methods accelerate this process by improving the supply of oxygen to the bacteria.

The first batches of vinegar produced by fermentation probably followed errors in the winemaking process. If must is fermented at too high a temperature, acetobacter will overwhelm the yeast naturally occurring on the grapes. As the demand for vinegar for culinary, medical, and sanitary purposes increased, vintners quickly learned to use other organic materials to produce vinegar in the hot summer months before the grapes were ripe and ready for processing into wine. This method was slow, however, and not always successful, as the vintners did not understand the process.

One of the first modern commercial processes was the "fast method" or "German method", first practised in Germany in 1823. In this process, fermentation takes place in a tower packed with wood shavings or charcoal. The alcohol-containing feed is trickled into the top of the tower, and fresh air supplied from the bottom by either natural or forced convection. The improved air supply in this process cut the time to prepare vinegar from months to weeks.

Most vinegar today is made in submerged tank culture, first described in 1949 by Otto Hromatka and Heinrich Ebner. In this method, alcohol is fermented to vinegar in a continuously stirred tank, and oxygen is supplied by bubbling air through the solution. Using this method, vinegar of 15% acetic acid can be prepared in only 2–3 days.

Anaerobic fermentation

Some species of anaerobic bacteria, including several members of the genus Clostridium, can convert sugars to acetic acid directly, without using ethanol as an intermediate. The overall chemical reaction conducted by these bacteria may be represented as:

C6H12O6 → 3 CH3COOH

More interestingly from the point of view of an industrial chemist, many of these acetogenic bacteria can produce acetic acid from one-carbon compounds, including methanol, carbon monoxide, or a mixture of carbon dioxide and hydrogen:

2 CO2 + 4 H2 → CH3COOH + 2 H2O

This ability of Clostridium to utilise sugars directly, or to produce acetic acid from less costly inputs, means that these bacteria could potentially produce acetic acid more efficiently than ethanol-oxidisers like Acetobacter. However, Clostridium bacteria are less acid-tolerant than Acetobacter. Even the most acid-tolerant Clostridium strains can produce vinegar of only a few per cent acetic acid, compared to some Acetobacter strains that can produce vinegar of up to 20% acetic acid. At present, it remains more cost-effective to produce vinegar using Acetobacter than to produce it using Clostridium and then concentrating it. As a result, although acetogenic bacteria have been known since 1940, their industrial use remains confined to a few niche applications.

Applications

2.5-litre bottle of acetic acid in a laboratory.
2.5-litre bottle of acetic acid in a laboratory.

Acetic acid is a chemical reagent for the production of many chemical compounds. The largest single use of acetic acid is in the production of vinyl acetate monomer, closely followed by acetic anhydride and ester production. The volume of acetic acid used in vinegar is comparatively small.

Vinyl acetate monomer

The major use of acetic acid is for the production of vinyl acetate monomer (VAM). This application consumes approximately 40% to 45% of the world's production of acetic acid. The reaction is of ethylene and acetic acid with oxygen over a palladium catalyst.

2 H3C-COOH + 2 C2H4 + O2 → 2 H3C-CO-O-CH=CH2 + 2 H2O

Vinyl acetate can be polymerised to polyvinyl acetate or to other polymers, which are applied in paints and adhesives.

Acetic anhydride

The condensation product of two molecules of acetic acid is acetic anhydride. The worldwide production of acetic anhydride is a major application, and uses approximately 25% to 30% of the global production of acetic acid. Acetic anhydride may be produced directly by methanol carbonylation bypassing the acid, and Cativa plants can be adapted for anhydride production.

Condensation of acetic acid to acetic anhydride

Acetic anhydride is a strong acetylation agent. As such, its major application is for cellulose acetate, a synthetic textile also used for photographic film. Acetic anhydride is also a reagent for the production of aspirin, heroin, and other compounds.

Vinegar

In the form of vinegar, acetic acid solutions (typically 5% to 18% acetic acid, with the percentage usually calculated by mass) are used directly as a condiment, and also in the pickling of vegetables and other foodstuffs. Table vinegar tends to be more diluted (5% to 8% acetic acid), while commercial food pickling generally employs more concentrated solutions. The amount of acetic acid used as vinegar on a worldwide scale is not large, but historically, this is by far the oldest and most well-known application.

Use as solvent

Glacial acetic acid is an excellent polar protic solvent, as noted above. It is frequently used as a solvent for recrystallisation to purify organic compounds. Pure molten acetic acid is used as a solvent in the production of terephthalic acid (TPA), the raw material for polyethylene terephthalate (PET). Although currently accounting for 5%–10% of acetic acid use worldwide, this specific application is expected to grow significantly in the next decade, as PET production increases.

Acetic acid is often used as a solvent for reactions involving carbocations, such as Friedel-Crafts alkylation. For example, one stage in the commercial manufacture of synthetic camphor involves a Wagner-Meerwein rearrangement of camphene to isobornyl acetate; here acetic acid acts both as a solvent and as a nucleophile to trap the rearranged carbocation. Acetic acid is the solvent of choice when reducing an aryl nitro-group to an aniline using palladium-on-carbon.

Glacial acetic acid is used in analytical chemistry for the estimation of weakly alkaline substances such as organic amides. Glacial acetic acid is a much weaker base than water, so the amide behaves as a strong base in this medium. It then can be titrated using a solution in glacial acetic acid of a very strong acid, such as perchloric acid.

Other applications

Dilute solutions of acetic acids are also used for their mild acidity. Examples in the household environment include the use in a stop bath during the development of photographic films, and in descaling agents to remove limescale from taps and kettles. The acidity is also used for treating the sting of the box jellyfish by disabling the stinging cells of the jellyfish, preventing serious injury or death if applied immediately, and for treating outer ear infections in people in preparations such as Vosol. Equivalently, acetic acid is used as a spray-on preservative for livestock silage, to discourage bacterial and fungal growth.

Glacial acetic acid is also used as a wart & verruca remover. A ring of petroleum jelly is applied to the skin around the wart to prevent spread, and 1-2 drops of glacial acetic acid are applied to the wart or verruca. Treatment is repeated daily. This method is painless and has a high success rate, unlike many other treatments. Absorption of glacial acetic acid is safe in small amounts.

Several organic or inorganic salts are produced from acetic acid, including:

Substituted acetic acids produced include:

Amounts of acetic acid used in these other applications together (apart from TPA) account for another 5%–10% of acetic acid use worldwide. These applications are, however, not expected to grow as much as TPA production.

Safety

Concentrated acetic acid is corrosive and must therefore be handled with appropriate care, since it can cause skin burns, permanent eye damage, and irritation to the mucous membranes. These burns or blisters may not appear until several hours after exposure. Latex gloves offer no protection, so specially resistant gloves, such as those made of nitrile rubber, should be worn when handling the compound. Concentrated acetic acid can be ignited with some difficulty in the laboratory. It becomes a flammable risk if the ambient temperature exceeds 39 °C (102 °F), and can form explosive mixtures with air above this temperature (explosive limits: 5.4%–16%).

The hazards of solutions of acetic acid depend on the concentration. The following table lists the EU classification of acetic acid solutions:

Concentration
by weight
Molarity Classification R-Phrases
10%–25% 1.67–4.16 mol/L Irritant (Xi) R36/38
25%–90% 4.16–14.99 mol/L Corrosive (C) R34
>90% >14.99 mol/L Corrosive (C) R10, R35

Solutions at more than 25% acetic acid are handled in a fume hood because of the pungent, corrosive vapour. Dilute acetic acid, in the form of vinegar, is harmless. However, ingestion of stronger solutions is dangerous to human and animal life. It can cause severe damage to the digestive system, and a potentially lethal change in the acidity of the blood.

Safety symbol
Safety symbol

 

Due to incompatibilities, it is recommened to keep acetic acid away from chromic acid, ethylene glycol, nitric acid, perchloric acid, permanganates, peroxides and hydroxyls.

See also

Uses

Chemistry

Related chemicals

References

  1. ^ a b http://webbook.nist.gov/cgi/cbook.cgi?ID=C64197&Units=SI&Mask=4#Thermo-Phase
  2. ^ Goldwhite, Harold (2003). New Haven Sect. Bull. Am. Chem. Soc. (September 2003).
  3. ^ Martin, Geoffrey (1917). Industrial and Manufacturing Chemistry, Part 1, Organic. London: Crosby Lockwood, pp. 330–31.
  4. ^ Schweppe, Helmut (1979). "Identification of dyes on old textiles". J. Am. Inst. Conservation 19(1/3), 14–23.
  5. ^ Jones, R.E.; Templeton, D.H. (1958). "The crystal structure of acetic acid". Acta Crystallogr. 11(7), 484–87.
  6. ^ James M. Briggs; Toan B. Nguyen; William L. Jorgensen. Monte Carlo simulations of liquid acetic acid and methyl acetate with the OPLS potential functions. J. Phys. Chem. 1991, 95, 3315-3322.
  7. ^ James B. Togeas. Acetic Acid Vapor: 2. A Statistical Mechanical Critique of Vapor Density Experiments. J. Phys. Chem. A 2005, 109, 5438-5444. DOI:10.1021/jp058004j
  8. ^ Dictionary of Organic Compounds (6th Edn.), Vol. 1 (1996). London: Chapman & Hall. ISBN 0-412-54090-8
  9. ^ Yoneda, Noriyki; Kusano, Satoru; Yasui, Makoto; Pujado, Peter; Wilcher, Steve (2001). Appl. Catal. A: Gen. 221, 253–265.
  10. ^ "Production report". Chem. Eng. News (July 11, 2005), 67–76.
  11. ^ Suresh, Bala (2003). "Acetic Acid". CEH Report 602.5000, SRI International.
  12. ^ Wagner, Frank S. (1978) "Acetic acid." In: Grayson, Martin (Ed.) Kirk-Othmer Encyclopedia of Chemical Technology, 3rd edition, New York: John Wiley & Sons.
  13. ^ Lancaster, Mike (2002) Green Chemistry, an Introductory Text, Cambridge: Royal Society of Chemistry, pp. 262–266. ISBN 0-85404-620-8.

External links

The content of this section  is licensed under the GNU Free Documentation License (local copy). It uses material from the Wikipedia article "Acetic acid" modified March 11, 2007 with previous authors listed in its history.