| Salivary gland | |
|---|---|
 |
|
| Salivary glands: #1 is Parotid gland, #2 is Submandibular gland, #3 is Sublingual gland | |
| Latin | glandulae salivariae |
| MeSH | Salivary+Glands |
| Dorlands/Elsevier | g_06/12391916 |
The salivary glands are exocrine glands that produce saliva.
Function
Salivach keeps the mouth and other parts of the digestive system moist.
Saliva also helps break down carbohydrates (with salivary amylase, formerly known as ptyalin) and lubricates the passage of food down from the oropharynx to the stomach.
Summary
A summary is provided in the following table.
| Salivary gland | Location | Secretion | Cranial nerve | Para-sym-pathetic ganglion | Con tribution to salivary volume |
|---|---|---|---|---|---|
| Parotid gland | near the ear | Serous | CN IX (glossopharyngeal nerve) | Otic | 25% |
| Sublingual gland | underneath the tongue | Mixed, mostly mucous | CN VII (facial nerve) | Sub-mandibular | 5% |
| Submandibular gland | ramus of the mandible | Mixed, mostly serous | CN VII (facial nerve) | Sub-mandibular | 70% |
| Ebner's glands | surrounding circumvallate papillae | Serous | - | - | - |
| minor glands | tongue, cheeks, lips, and palate | Mucous | - | - | - |
Salivary glands are innervated by the parasympathetic and sympathetic branches of the autonomic nervous system.
Histology
The glands are enclosed in a capsule of connective tissue and internally divided into lobules. Blood vessels and nerves enter the glands at the hilum and gradually branch out into the lobules.
Cells
There are 3 main types of cells that are found in the major salivary glands:
- Serous cells, which are pyramidal in shape and are joined to usually form a spherical mass of cells called acinus, with a small lumen in the centre. Serous demilunes are found in the submandibular gland.
- Mucous cells are usually cuboid in shape and organised as tubules, consisting of cylindrical arrays of secretory cells surrounding a lumen. These cells produce glycoproteins that are used for the moistening and lubricating functions of saliva.
- Myoepithelial cells surround each secretory portion and are able to contract to accelerate secretion of the saliva.
Ducts
In the duct system, the lumens formed by the secretory cells empty into intercalated ducts, which in turn join to form striated ducts. These drain into ducts situated between the lobes of the gland (called interlobar ducts or excretory ducts).
The main duct of the salivary glands ultimately empties into the mouth.
Innervation
Salivary glands are innervated, either directly or indirectly, by the parasympathetic and sympathetic arms of the autonomic nervous system.
- Parasympathetic innervation to the salivary glands is carried via cranial nerves. The parotid gland receives its parasympathetic input from the glossopharyngeal nerve (CN IX) via the otic ganglion, while the submandibular and sublingual glands receive their parasympathetic input from the facial nerve (CN VII) via the submandibular ganglion.
- The sympathetic nervous system affects salivary gland secretions indirectly by innervating the blood vessels that supply the glands.
Role in disease
- See mumps (parotiditis epidemica) and Sjögren syndrome.
Salivary duct calculus may cause blockage of the ducts, causing pain and swelling of the gland.
Tumors of the salivary glands may occur. These are usually benign, but may be malignant. The most common type of benign tumor is pleomorphic adenoma, followed by Warthin's tumor. The most common malignant tumor is mucoepidermoid carcinoma.
Diagnostic investigation
A sialogram is a radiocontrast study of a salivary duct.
References
- ^ Douglas F. Paulsen (2000). Histology & cell biology: examination and board review. New York: Lange Medical Books, McGraw-Hill. ISBN 0-8385-0593-7.
